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在长期COVID中,与认知相关的灰质体积变化显示出性别特异的模式

Antonia Toepffer¹, Marlene Früh¹, Tonia Rocktäschel¹

¹Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.

Frontiers in psychiatry

|October 22, 2025

概括

长期COVID影响认知功能,在男性和女性中观察到明显的脑灰质体积变化. 这些性别特异性的变化表明了不同的潜在机制,需要进一步研究个性化治疗.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
公共卫生公共卫生

背景情况:

COVID-19的长期影响,称为长期COVID,包括认知障碍.
在COVID-19进展和长期COVID患病率方面注意到性别差异.
长期COVID的认知障碍是一个重大问题,需要研究其潜在机制.

研究的目的:

研究长期COVID患者认知障碍的性别差异.
在长期COVID患者中探索认知障碍和灰质体积 (GMV) 变化之间的关联.
为了确定COVID-19后认知障碍的性别特异性大脑结构相关物.

主要方法:

使用3特斯拉MRI和基于voxel的形态测量 (VBM) 来分析大脑结构.
长期COVID患者 (n=64) 与健康对照 (HC) 组 (n=30) 的比较.
在性别特定分析中,将长期COVID患者分为认知保持 (PCn,MoCA ≥26) 和认知受损 (PCcog,MoCA <26) 组.

主要成果:

在长期COVID患者中发现了显著的GMV变化,具有共享和性别特定的区域变化.
雌性在前额,边缘和二脑区域表现出GMV变化.
男人表现出更广泛的GMV变化,影响新皮层区域,如头顶,尾和运动皮层.

结论:

长期COVID的认知障碍与两性GMV变化有关.
观察到的基因转基因病毒变化的性别特异性模式表明了不同的潜在病理生理机制.
需要进一步研究,以了解功能影响,并制定针对长期COVID认知障碍的个性化治疗策略.

关键词:

在 COVID-19 疫情中,转基因病毒 GMV 转基因病毒莫卡 (MOCA) 是一种可怕的植物.这就是VBM的VBM.认知障碍是一种认知障碍.长时间的Covid.在后COVID时期.性别差异的性别差异.

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