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A2AR--STAT1 (Y701) -HLA-E轴作为放射治疗耐药三阴性乳腺癌中潜在的免疫调节途径

Young Shin Ko1,2, Hana Jin1, So Eun Lee1,2

  • 1Department of Pharmacology, College of Medicine, Institute of Medical Sciences, Gyeongsang National University, Jinjudaero 816 Bungil 15, Jinju 52727, Republic of Korea.

Carcinogenesis
|October 22, 2025
PubMed
概括

三阴性乳腺癌 (TNBC) 对放射治疗的耐药性与增加的HLA-E表达有关. 针对A2AR-STAT1通路,使用弗鲁达拉宾或莫纳利祖马布等药物,可以克服这种抗药性.

关键词:
在A2A受体中,A2A受体是在HLA-E的基础上,HLA-E在 NK 细胞中,NK 细胞是 NK 细胞.酸-STAT1 (Y701) 的使用情况抗辐射治疗的TNBC

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