[凝血概况PT,FBG,FDP,D-D作为RA和pSS炎症免疫的疾病预测因素]
Wenwen Min1, Lei Wan2, Feng Li1
1Department of Rheumatology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
概括
凝血指数,如前列血时间 (PT) 和纤维素原 (FBG),对于诊断类风湿性关节炎 (RA) 的信息比原发性Sjögren更为丰富.
科学领域:
- 风湿病学和免疫学
- 血液学 血液学 血液学
- 生物化学 生物化学
背景情况:
- 类风湿性关节炎 (RA) 和原发性Sjögren综合征 (pSS) 是具有重叠症状的慢性炎症性自身免疫性疾病.
- 凝血障碍在自身免疫性疾病中越来越多地被认可.
- 了解RA和pSS中的凝血指数表达对于诊断和管理至关重要.
研究的目的:
- 调查RA和pSS患者中各种凝血指数的表达水平.
- 在这些条件下探索凝血指数,炎症和免疫功能之间的关系.
- 评估RA和pSS的凝血指数的诊断实用性.
主要方法:
- 一项涉及61名RA患者,61名pSS患者和61名健康对照者的比较研究.
- 凝血指数的测量:PT,INR,TT,FBG,APTT,FDP,以及D-D. 这些都是凝血指数的测量.
- 分析与炎症标记物 (hs-CRP,ESR) 和免疫标记物 (RF,CCP,anti-SSA,anti-SSB) 的关联.
- ROC曲线分析用于诊断准确性和关联规则分析用于相关性.
主要成果:
- 在RA,pSS和对照组中观察到PT,FBG,TT,FDP和D-D水平的显著差异.
- 与pSS和对照组相比,RA患者的PT,FBG,FDP和DD水平较高.
- 凝血指数,特别是FBG和D-D,证明了RA的高诊断准确性,并与RA和pSS的炎症和免疫标志物显著相关.
结论:
- 与pSS相比,凝血指数,特别是PT,FBG,FDP和DDD,对于早期诊断和评估RA的疾病严重程度更有价值.
- 这些凝血标记可以作为确认RA诊断的重要预测因素.
- 凝血状态与炎症和免疫失调密切相关,无论是RA还是pSS.
相关概念视频
01:24T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
476
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
476
01:23Rheumatic Heart Disease I: Introduction
426
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
426