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大豆异黄可以通过表观遗传修饰,预防大鼠高脂肪饮食引起的骨质损失
Perry C Caviness1,2, Beau Belcher1, Oxana P Lazarenko1,2
1Arkansas Children's Nutrition Center, Little Rock, Arkansas, USA.
概括
大豆异黄 (Isofs) 通过调节表观遗传标志物和减少炎症来保护大鼠免受高脂肪饮食 (HFD) 诱导的骨质损失. 这种饮食干预措施支持骨健康,尽管HFD面临挑战.
科学领域:
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 高脂肪饮食 (HFD) 诱导肥胖,胰岛素抵抗,并对骨代谢产生负面影响.
- 已知大豆异黄 (Isofs) 有助于结缔组织代谢.
- 在HFD条件下,大豆Isofs对骨发育的保护作用尚不清楚.
研究的目的:
- 为了研究大豆异黄 (Isof) 补充剂对高脂肪饮食 (HFD) 的老鼠骨发育,形态和重塑的影响.
- 探索潜在的分子机制,包括表观遗传修饰,是Isof骨保护作用的基础.
主要方法:
- 雄性Sprague-Dawley大鼠在8周内被食控制饮食或含有或不含有大豆Isof补充剂的HFD.
- 用微型CT和三点曲测试来评估骨质,形态和强度.
- 分析了血清标记物,基因表达 (Ezh2,NFATc1) 和表观遗传修饰 (H3K27me3,DNA甲基化).
主要成果:
- 消费HFD导致体重增加,骨头长度增加,脂肪增加和胰岛素抵抗.
- 大豆Isof补充剂防止了HFD诱导的骨质和强度的减少.
- 异位素降低了非化自由脂肪酸 (NEFA) 水平,改善了HFD诱导的Ezh2和H3K27me3的增加,并阻止了骨质结晶标记物的表达.
- 补充Isof抑制了HFD诱导的骨DNA甲基化增加,并与减少NEFA和Ezh2表达相关.
结论:
- 在幼鼠中,HFD会破坏骨和脂肪组织的发育和重塑.
- 饮食大豆Isofs保护免受HFD诱导的骨损伤.
- 伊索夫的保护机制可能涉及通过Ezh2调节调节组织素和DNA甲基化.
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