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相关概念视频

RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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相关实验视频

Updated: Jan 14, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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CIRCpedia v3:用于循环RNA表征和功能探索的交互式数据库.

Si-Nan Zhai1,2, Yu-Yao Zhang1, Mo-Han Chen1

  • 1Center for Molecular Medicine, Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

Nucleic acids research
|October 22, 2025
PubMed
概括

CIRCpedia v3 是一个扩展的存储器,用于循环RNA (circRNAs) 和来自内核 lariats (ciRNAs) 的循环RNA. 它为分子分析,比较分析和功能预测提供了新的工具,以推进circRNA研究.

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 循环RNAs (circRNAs) 和来自内子 lariats (ciRNAs) 的循环RNAs扮演着不同的生物学角色,但它们的分子特征和功能需要进一步阐明.
  • 对circRNA的系统性表征对于理解它们在生物过程和疾病中的参与至关重要.

研究的目的:

  • 介绍CIRCpedia v3,一个增强的存储库,用于在多个物种中注释circRNAs和ciRNAs.
  • 为circRNA研究提供先进的工具,包括命名,比较分析和功能预测.

主要方法:

  • 在20个物种中对2413个测序数据集进行分析,以识别和注释circRNAs和ciRNAs.
  • 开发一个互动平台,实时进行比较分析和可视化.
  • 整合工具包以识别可编辑的基位,预测亚细胞定位,检测降解信号,预测m6A位点,编码潜力评估和原始/siRNA设计.

主要成果:

  • 在CIRCpedia v3.3中识别和注释了超过200万个循环RNA.
  • 引入社区推的命名体系,用于循环/线性单体形态动态的定量比较.
  • 开发综合工具包,使 circRNAs 的综合分子分析和功能预测成为可能.

结论:

  • CIRCpedia v3显著扩展circRNAs和ciRNAs的注释,促进跨物种表达和分子表征.
  • 集成的工具包使研究人员能够优先考虑circRNA候选者,并加速机制发现和治疗开发.
  • CIRCpedia v3 作为一个有价值的资源,促进生物和疾病背景的 circRNA 研究.