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仿生自导纳米引擎可以促进活性免疫疗法

Yicheng Ye^1,2, Hong Wang^1,2, Jiamiao Jiang²

¹The People's Hospital of Pingshan Shenzhen, Pingshan Hospital, Southern Medical University, Shenzhen 518100, China.

|October 22, 2025

概括

这项研究引入了一种新的Janus纳米运动系统,可以积极向瘤. 这些纳米驱动器增强药物输送,并激活免疫反应,以改善癌症治疗.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

传统的纳米药物在瘤透和释放损伤相关分子模式 (DAMPs) 方面面临挑战.
被动纳米载体的有限疗效阻碍了有效的瘤治疗.

研究的目的:

开发一个仿生Janus纳米运动系统,用于增强瘤治疗.
为了改善化疗药物输送,瘤透和免疫反应激活.

主要方法:

制造Janus HZ-AD纳米发动机,其中包括l-氨酸,黄金纳米粒子和ZIF8与DOX加载.
利用阿尔金因的化学反应行为,自主导航到过氧化.
使用NIR辐射进行活跃运动并触发药物释放和Zn2+释放.

主要成果:

纳米发动机展示了到瘤部位的自我导航,并增强了瘤的深度透.
活跃运动促进了细胞吸收,DOX释放和Zn2+释放,诱导热.
该系统激活了抗瘤免疫反应,抑制了瘤生长,复发和转移.

结论:

开发的纳米发动机提供了结合化疗向,运动诱导透和光化学免疫治疗的三模式治疗策略.
该系统解决了传统纳米药物的局限性,显示了癌症治疗中治疗进步的潜力.

关键词:

增强的透能力提高了透能力.免疫疗法免疫疗法纳米引擎是一个纳米引擎.热致灭 (pyroptosis) 是一种致的过程.自我指导的指导方式

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