riboflavin 补充剂用于降低成人血压
Kathryn E Bradbury1, Sean Coffey2, Nikki Earle3
1School of Population Health, University of Auckland, Auckland, New Zealand.
The Cochrane database of systematic reviews
|October 22, 2025
概括
关于 riboflavin 补充剂的证据非常不确定.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 血压升高会增加心血管疾病的风险.
- рибофлавин (维生素B2) 正在研究其降低血压的潜力,特别是在具有MTHFR C677T多态的个体中.
- 本综述评估了 riboflavin 补充剂在血压管理中的有效性和安全性.
研究的目的:
- 评估与安慰剂相比,利博弗拉补充剂对降低静缩和放缩血压的益处和危害.
- 评估利博弗拉对抗高血压药物的使用和不良事件的影响.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 搜索包括主要数据库 (科克兰高血压,CENTRAL,MEDLINE,Embase,科学网) 到2024年10月.
- 包括4个带有374名参与者的RCT;使用Cochrane RoB 2工具评估偏差风险. 小组分析包括MTHFR C677T基因型.
主要成果:
- 关于 рибофлавин对静缩血压 (MD -1.94 mmHg) 和静缩血压 (MD -3.03 mmHg) 的影响的证据非常不确定,原因是很少有偏差风险高的研究证据的确定性很低.
- 没有明确确确定的血压显著降低.
- 一个RCT显示了低确定性证据,表明 riboflavin 和对照组之间的不良事件几乎没有差异.
结论:
- 目前关于口服 рибофлавин 补充剂对血压的影响的证据非常不确定.
- 包含的研究具有高偏差风险,限制了最终结论.
- 需要进行更大规模,更高质量的随机对照试验,以确定 рибофлавин降低血压的疗效.
相关概念视频
Hypertension IV: Drug Therapy and Lifestyle Modifications
618
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
618
Hypertension and Regulation of Blood Pressure
3.7K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.7K
Antihypertensive Drugs: Direct Renin Inhibitors
1.3K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.3K
Alterations in Blood Pressure
2.0K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.0K
Factors affecting Blood pressure
6.5K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
6.5K
Hypertension V: Nursing Management
355
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
355


