动脉硬与小和大纤维神经病变有关:马斯特里赫特研究
Chidera Okoro1,2, Carla J H van der Kallen1,2, Sara B A Mokhtar1,2,3,4
1CARIM School for Cardiovascular Diseases, Maastricht University (UM).
Journal of hypertension
|October 22, 2025
概括
动脉硬化,以带 - 骨脉冲波速率 (cfPWV) 衡量,与影响眼睛和神经的各种神经病变有关. 这种关联适用于不同性别和葡萄糖代谢状态.
科学领域:
- 心血管健康 心血管健康
- 神经学 神经学
- 眼科医生 眼科 眼科
背景情况:
- 动脉硬是心血管健康的指标.
- 神经病,影响眼睛和四肢的神经,可以显著影响生活质量.
- 了解动脉硬和神经病变之间的联系对于早期检测和干预至关重要.
研究的目的:
- 为了研究动脉硬性之间的联系,用带-大腿脉冲波速率 (cfPWV) 来量化,和多种形式的神经病变.
- 根据性别和葡萄糖代谢状态来探索这些关联中的潜在差异.
主要方法:
- 从"马斯特里赫特研究"中对9,188名参与者的横截面分析.
- 使用cfPWV评估动脉硬度.
- 通过视网膜神经层厚度,视网膜敏感度,角膜神经测量,外围神经传导速度,振幅和振动感知值来评估神经病变.
- 对混因子进行调整的线性回归模型,对性别和葡萄糖代谢进行相互作用测试.
主要成果:
- 动脉硬度增加与视网膜神经层厚度,视网膜敏感度,角膜神经测量,外围神经传导速度和神经幅度的减少显著相关.
- 较高的动脉硬与增加的外周振动感知值相关.
- 这些关联在性别和葡萄糖代谢层 (正常,糖尿病前期,2型糖尿病) 之间是一致的.
- 对于经或经神经幅度,没有发现显著的关联.
结论:
- 动脉硬化与小纤维和大纤维神经病变有关.
- 这些发现表明,血管健康和神经损伤之间存在潜在的联系.
- 需要进一步的纵向研究来确定因果关系.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
349
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
349
Peripheral Artery Disease I: Introduction
310
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
310
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
458
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
458
Local Anesthetics: Differential Sensitivity of Nerve Fibers
1.4K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.4K
Arteries of Lower Limbs
4.2K
The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular...
4.2K
Peripheral Artery Disease IV: Nursing Management
347
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
347


