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解码时空空间微环境变化在口腔致癌的解码

D Yang¹, Z Wang², Q Shang¹

¹State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of dental research

|October 22, 2025

概括

口腔致癌包括瘤微环境的变化. 调控性B细胞 (Bregs) 通过TGF-β信号与高IGFBP2的口腔上皮原生细胞 (OEPCs) 相互作用,推动早期癌症的发展.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

口腔致癌是一个多阶段的过程,涉及表皮细胞变化和关键的微环境变化.
了解这些动态的微环境变化是防止口腔癌进展的关键.

研究的目的:

用多omics时空分析来研究口腔粘膜致癌过程中的微环境重塑.
确定关键的细胞参与者和参与口腔癌发展的信号通路.

主要方法:

在致癌过程中口腔粘膜的多omics时空分析.
口腔上皮原生细胞 (OEPC) 和调控性B细胞 (Bregs) 的识别和表征.
空间转录组学通过TGF-β信号通路来确认细胞的近距离和相互作用.

主要成果:

确定了一组具有高胰岛素类生长因子结合蛋白2 (IGFBP2) 表达率的OEPCs子集,显示出增加的增殖和减少的分化.
在癌前阶段观察到Bregs的透增加,通过TGF-β信号与IGFBP2高的OEPC相互作用.
在晚期癌症中,Breg透率平稳或下降,这表明了特定阶段的调节机制.

结论:

该研究揭示了口腔癌微环境的演变,突出了Bregs和IGFBP2高的OEPCs的作用.
通过TGF-β信号传递的Bregs和OEPCs之间的相互作用导致细胞平衡的破坏和潜在的恶性瘤.
专注于癌前阶段对于理解和潜在地干预口腔癌发生至关重要.

关键词:

疾病进展 B-淋巴细胞口腔白血病 (Leukoplakia) 是一种口腔白血病.在口腔的粘膜.监管部门的监管机构.干细胞是干细胞的组成部分.转化增长因子β1的转化增长因子β1

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