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痴呆症患者的牙损失:瑞典基于登记的队列研究
M Mohammadi1,2, J Holmer1,3, H Imberg4,5
1Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Journal of dental research
|October 22, 2025
概括
牙损失是口腔健康不佳的标志,在痴呆症患者中进行了研究. 这项研究没有发现牙脱落与增加的死亡率或新诊断为痴呆症的个体更快的认知衰退之间的联系.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 口腔健康 口腔健康
背景情况:
- 心血管疾病,吸烟和糖尿病等痴呆症风险因素与口腔健康不良和牙周病有关.
- 牙损失是口腔健康妥协的标志物,目前正在研究其系统性影响,包括对认知功能的潜在影响.
研究的目的:
- 评估牙损失作为痴呆症的预后指标.
- 在痴呆症患者中评估口腔健康受损 (定义为牙损失) 与死亡风险和认知衰退进展之间的关联.
主要方法:
- 一项基于登记的队列研究,使用瑞典全国健康和质量保证登记处的链接.
- 包括3,361名被诊断患有痴呆症的人 (2010-2013) 随访至2018年.
- 根据牙数量 (严重:<10,中度:10-19,参考:≥20) 和分析的死亡率和认知衰退 (迷你精神状态检查得分) 分类参与者.
主要成果:
- 痴呆症诊断时的牙损失与共变性调整后的死亡率增加没有独立相关 (HR 1.12 [95% CI,0.97-1.28] 严重损失与参考).
- 通过迷你精神状态检查得分测量的认知衰退,在牙损失组之间没有统计学上显著的差异.
- 在强大的共同变量控制后,在新诊断患有痴呆症的个体中,牙脱落和增加的死亡率或认知衰退之间没有观察到任何关联.
结论:
- 没有发现牙损失是新诊断患有痴呆症的个体死亡率或认知衰退的独立预后指标.
- 需要进一步的研究,以澄清牙脱落作为独立风险因素或痴呆症预后的贡献标记物的作用.
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