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设计抗癌多尿素生物体:核心外电荷/疏水性调节的作用

Adriana Cruz1, José Barbosa1, Nuno Bernardes1

  • 1iBB-Institute for Bioengineering and Biosciences, and Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Lisbon, Portugal. vasco.bonifacio@tecnico.ulisboa.pt.

Biomaterials science
|October 22, 2025
PubMed
概括

两种新型生物体通过破坏癌细胞膜和向线粒体,表现出内在的抗癌活性. 这些合成模仿抗癌的合成模仿剂为癌症治疗开发提供了一个有希望的新途径.

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...