Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.1K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Ouabain exerts protective effects on SH-SY5Y cells upon Zika virus infection.

Virology journal·2026
Same author

Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice.

Cells·2024
Same author

Genome-Scale Analyses Reveal Roadblocks to Monkey Cloning.

Cellular reprogramming·2024
Same author

Gene Regulatory Networks: Improving Inferences with Transfer Learning.

Cellular reprogramming·2023
Same author

Reference genes for gene expression profiling in mouse models of <i>Listeria monocytogenes</i> infection.

BioTechniques·2023
Same author

Cloning by SCNT: Integrating Technical and Biology-Driven Advances.

Methods in molecular biology (Clifton, N.J.)·2023

相关实验视频

Updated: Jan 14, 2026

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.6K

细胞重编程和微流体学使老年捐赠者能够大规模生产状体.

Marcelo Tigre Moura1

  • 1Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brasil.

Cellular reprogramming
|October 22, 2025
PubMed
概括

研究人员开发了一种新方法,从 rhesus 子中创建 blastoids 或早期胚胎模型. 这一突破使得开发生物学研究使用非人类灵长类动物的Blastoids取得了进展.

科学领域:

  • 发展生物学 发展生物学
  • 干细胞研究 干细胞研究
  • 灵长类动物模型

背景情况:

  • 芽细胞,模仿植入前胚胎的干细胞模型,对于研究早期发育和疾病至关重要.
  • 现有的Blastoid技术在老鼠和人类中是先进的,但在非人类灵长类动物中是有限的.

研究的目的:

  • 为了建立一个有效的协议,从 rhesus 子生产 blastoids.
  • 为了在细胞和分子层面上描述这些非人类灵长类动物的Blastoid.
  • 探索 rhesus 子作为哺乳动物发育模型的潜力.

主要方法:

  • 利用细胞重编程技术,从年轻和老年 rhesus 子中产生 体.
  • 应用了标准测定方法,以全面描述布拉斯体的特性.
  • 整合了Blastoid生产协议与微流体进行规模生产.

主要成果:

  • 成功开发了一种高效的协议,用于 rhesus 子的布拉斯泰德生产.
  • 描述了Blastoids的特征,证实了它们的细胞和分子忠实性.
  • 使用微流体学演示了可扩展的布拉斯泰德生成.

结论:

关键词:
澳门子 (Macaca mulatta) 是一个有趣的动物.胚胎模型 胚胎模型诱导了多能性的多能性.微流体学 在微流体学方面核移植 - 核移植

更多相关视频

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

20.4K
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
11:42

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

6.5K

相关实验视频

Last Updated: Jan 14, 2026

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.6K
Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

20.4K
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
11:42

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

6.5K
  • 在研究早期哺乳动物发育方面, rhesus 子的 Blastoids 是一个重大进步.
  • 这种模型对研究灵长类动物的发育过程和疾病充满希望.
  • 对布拉斯分化的进一步研究可以确定 rhesus 子作为关键的 * ex vivo * 模型物种.