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艾米卡辛的毒性重新审视:在高风险的治疗场景中,托西菲林可以提供保护
Nada Moustafa1, Mona B Abd El-Latif2, Alyaa Farid3
1Biotechnology Department, Faculty of Science, Cairo University, Giza, Egypt.
AMB Express
|October 22, 2025
概括
氧菲林 (PTX) 通过减少氧化应激和炎症来保护免受阿米卡辛 (AMK) 诱导的和肝损伤. 这表明PTX可以提高AMK抗生素治疗的安全性.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 腎病學和肝病學.
- 炎症和氧化应激研究研究
背景情况:
- 阿米卡辛 (AMK) 是格拉姆阴性感染的关键抗生素,导致显著的毒性和肝毒性.
- 这种器官损伤主要是由氧化应激和炎症通路驱动的.
- 托西菲林 (PTX),以其抗氧化和抗炎作用而闻名,是一种潜在的治疗剂.
研究的目的:
- 评估托西菲林 (PTX) 对阿米卡辛 (AMK) 诱导的毒性和肝毒性的保护作用.
- 研究涉及氧化应激和炎症的潜在机制.
- 为了确定PTX作为辅助疗法的剂量依赖疗效.
主要方法:
- 雄性BALB/c小鼠在28天内服用AMK (100毫克/公斤/天) 或不服用不同剂量的PTX (50或100毫克/公斤/天).
- 评估了和肝功能的生物化学标记物,氧化应激标记物 (MDA) 和炎症性细胞因子 (IL-17).
- 对脏和肝脏组织进行了组织病理学检查,以评估结构损伤.
主要成果:
- 抗氧化基因治疗显著增加了和肝损伤标志物,增加了氧化应激,并上调了IL-17.
- 同时服用PTX,特别是100mg/kg,使生物化学参数正常化,氧化和炎症标志物减少.
- 组织病理学分析显示,PTX保留了组织结构,以剂量依赖的方式减轻了AMK诱导的损伤.
结论:
- 托西菲林在小鼠中显示出显著的保护作用,防止阿米卡辛诱导的毒性和肝毒性.
- 通过恢复抗氧化防御和抑制炎症,PTX有效地减轻AMK毒性.
- 作为一种安全有效的辅助疗法,PTX显示出有前途的承诺,以增强阿米卡辛的临床使用.
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