与共发性自身免疫性疾病相关的IgG4相关疾病:来自大型队列的回顾性研究
Xinli Yang1,2, Yuxie Nie1,2, Jingna Li1,2
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Clinical rheumatology
|October 22, 2025
概括
在患有IgG4相关疾病 (IgG4-RD) 的患者中,9.67%患有并发性自身免疫疾病 (AID),IgG4水平较低,但治疗和预后相似. 这些发现凸显了IgG4-RD和艾滋病之间的复杂相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 是一种复杂的纤维炎症状况.
- 需要进一步调查IgG4-RD与其他自身免疫性疾病 (AID) 的共存.
- 了解这些并发症对于全面的患者管理至关重要.
研究的目的:
- 研究IgG4相关疾病 (IgG4-RD) 患者的临床特征,治疗策略和预后,这些患者患有并发性自身免疫疾病 (AID).
- 为了比较具有并发性艾滋病患者和没有并发性艾滋病患者的IgG4-RD患者.
- 在这个患者队列中探索AIDs的特定亚型和特征.
主要方法:
- 对879名以前没有接受过治疗的IgG4-RD患者进行了回顾性分析.
- 分类为艾滋病阳性 (AID-Pos) 和艾滋病阴性 (AID-Neg) 组.
- 组间临床特征,实验室检测结果,治疗方法和预后的比较,包括艾滋病的子组分析 (全身性与器官特异性).
主要成果:
- 在IgG4-RD中并发性艾滋病的患病率为9.67% (85/879),常见的艾滋病包括白风,全身血管炎,牛皮,哈希莫托甲状腺炎和类风湿性关节炎.
- 与AID-Neg患者相比,AID-Pos患者的血清IgG4水平较低.
- 系统性AID与较高的红细胞沉积率 (ESR) 和IgG1水平相关;然而,治疗和预后在各组都相似,AID-Neg患者显示更多的多器官参与.
结论:
- 在相当一部分IgG4相关疾病 (IgG4-RD) 患者中观察到并发性自身免疫性疾病 (AID).
- 患有并发性艾滋病的IgG4-RD患者往往具有较低的血清IgG4水平和较少的多器官参与.
- 伴随性艾滋病的存在似乎不会显著改变IgG4-RD的治疗反应或长期预后.
更多相关视频
相关概念视频
Autoimmune Disorders
1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.5K
Genome-wide Association Studies-GWAS
15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.3K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
476
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
476


