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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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转移研究的微生理系统:一个逐步的方法.

Vira Sharko1,2, Ignacio Ochoa3,4,5, Estela Solanas6,7

  • 1Tissue Microenvironment (TME) Lab, Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, 50018, Spain.

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概括

微生理系统 (MPS) 提供先进的模型来研究癌症转移,克服传统方法的局限性. 这些系统能够详细研究瘤细胞的入侵,循环和殖民,以开发向疗法.

关键词:
癌症 癌症 癌症 癌症转移 转移 转移 转移微流体学 微流体学微生理系统是微生理系统.瘤微环境是一个微环境.

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科学领域:

  • 在瘤学瘤学.
  • 生物技术是生物技术.
  • 生物医学工程 生物医学工程

背景情况:

  • 癌症转移是一个复杂的多阶段过程,是癌症死亡的主要原因.
  • 传统的体外和动物模型在复制转移的动态和多方面的性质方面存在局限性.
  • 微生理系统 (MPS) 为研究具有生理相关性和实验控制的转移提供了一个有希望的替代方案.

研究的目的:

  • 审查微生理系统 (MPS) 的最新进展,以建模癌症转移的关键阶段.
  • 探索MPS如何回顾瘤细胞在转移过程中遇到的生物和生物机械挑战.
  • 突出MPS在理解转移机制和告知向治疗开发方面的潜力.

主要方法:

  • 对转移研究的微生理系统设计的最新文献的综述.
  • 对MPS配置 (水平,垂直) 和血管化策略的分类.
  • 分析MPS如何模拟特定的转移性过程:入侵,输血,循环,输血和殖民.

主要成果:

  • MPS设计有效地模拟瘤微环境相互作用 (矩阵,层细胞,机械力) 驱动上皮细胞-介质细胞过渡和入侵.
  • MPS可以复制血管动力学,这对血管内,血液循环和血管外都至关重要.
  • 正在开发特定器官的MPS环境,以研究殖民化和有机化.

结论:

  • 微生理系统是解剖具有高度生理相关性的复杂转移机制的强大工具.
  • 在MPS设计和应用方面的进步对于了解癌症进展和开发有效的向疗法至关重要.
  • MPS为临床前癌症研究提供了一个有前途的平台,弥合了传统模型和临床结果之间的差距.