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Updated: Jan 6, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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人环素减弱了依赖Nrf1的蛋白质分解途径,并增强了蛋白质酶体抑制剂的细胞毒性

Janakiram R Vangala1, Madison A Ward1, Bader Albalawi1

  • 1Department of Pathology, Virginia Commonwealth University, Richmond, 23298-0662, Virginia.

Molecular biology of the cell
|October 22, 2025
PubMed
概括

像多克索鲁比辛这样的类人环素抑制了Nrf1转录因子,这驱动了多发性骨髓瘤中对蛋白酶体抑制剂的抵抗. 这种独立于DNA损伤的作用可能有助于克服治疗耐药性.

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