在肌原性进展过程中暂时的受体潜在通道激活的影响和在自愿运动过程中骨肌功能
Hiroyuki Yamamoto1, Kota Kojima1, Shuto Kasai1
1Department of Health and Nutritional Sciences, Faculty of Food and Health Sciences, Aichi Shukutoku University, Japan.
Bioscience, biotechnology, and biochemistry
|October 22, 2025
概括
素和薄荷醇通过改变肌重链表达和促进能量代谢来影响骨肌肉. 这些化合物还可以减少脂肪质量并增强体育活动,这表明对肌肉质量有好处.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 代谢研究研究 代谢研究
背景情况:
- 暂时受体潜能 (TRP) 通道激动剂,素和薄荷醇,影响能量代谢.
- 它们对骨肌肉分化和质量的特定影响仍然在很大程度上未被描述.
研究的目的:
- 研究素和薄荷醇对骨肌肉分化和质量的影响.
- 探索它们对肌肉表型和新陈代谢的影响背后的分子机制.
主要方法:
- 使用骨肌细胞进行体外研究,以评估基因表达变化.
- 在体内实验中,在自愿运行期间,在动物身上进行局部应用的实验.
- 分析关键肌肉蛋白质,能量代谢标志物和身体活动水平.
主要成果:
- 素和薄荷素都调节了髓重链 (MYH) 表达,上调 MYH4 和下调 MYH2 和 MYH7.
- 素增加了解蛋白 (UCP) 3,而薄荷醇增加了UCP2,UCP3和M型肌酸酶.
- 在体内,素减少了脂肪质量和增加了运动运动活动;薄荷醇增强了光相活动.
- 这两种治疗都提高了肌肉MYH4,UCP2,UCP3,并抑制了肌静素的表达.
结论:
- 素和薄荷醇直接影响骨肌肉细胞表型和新陈代谢.
- 这些化合物可以调节肌肉基因表达和与能量相关的蛋白质.
- 结合增加体力活动,它们为改善肌肉质量和代谢健康提供了潜在的策略.
相关概念视频
Relaxation of Skeletal Muscles
5.5K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
5.5K
Generation of Action Potential in Skeletal Muscles
8.4K
Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...
8.4K
Motor Unit Stimulation
3.5K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.5K
Excitation-Contraction Coupling in Skeletal Muscles
14.0K
Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action...
When an action...
14.0K
Smooth Muscle Contraction
7.2K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
7.2K
Cross-bridge Cycle
122.2K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
122.2K


