如何在一生中暴露于环境不利因素加速生物衰老? 心理症状的作用 心理症状的作用
Christina Kamis1, Wei Xu2, Amy Schultz3
1Department of Sociology, University of Illinois Urbana-Champaign, Urbana, Illinois, United States.
概括
邻居处于不利的环境加快了生物衰老,心理压力介导了这一效应的10-13%. 焦虑特别影响像GrimAge和DunedinPACE这样的表观遗传钟,突出了健康的社会决定因素.
科学领域:
- 公共卫生 公共卫生
- 社会流行病学 社会流行病学
- 老年学是一门学科.
背景情况:
- 在一生中暴露于社会经济劣势与加速的生物衰老有关.
- 了解推动健康差异的机制对于公共卫生干预至关重要.
- 心理症状可能会调解不利和衰老之间的关系.
研究的目的:
- 调查心理症状在累积邻居劣势和加速生物衰老之间的联系中的作用.
- 检查直接和间接的路径,从邻居的劣势到表观遗传加速的年龄.
- 评估整体痛苦,抑郁,焦虑和压力的调解效应.
主要方法:
- 利用研究表观遗传,气候变化,衰老和邻居劣势 (REWARD) 研究.
- 通过使用住宅历史评估累积的邻里劣势.
- 使用了三种表观遗传时钟 (GrimAge,PhenoAge,DunedinPACE) 和心理症状措施的路径分析.
主要成果:
- 累积的邻居劣势直接和间接地加速了表观遗传衰老.
- 心理困扰调解了邻居处于不利地位对衰老的影响的10-13%.
- 焦虑是GrimAge和DunedinPACE表观遗传钟的重要调解者.
结论:
- 背景不利是整个生命过程中健康的重要社会决定因素.
- 心理症状,特别是痛苦和焦虑,是关键机制,将不利状况与加速衰老联系在一起.
- 调查结果强调了解决社会决定因素的重要性,以减少衰老中的健康差异.
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