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Updated: Jan 14, 2026

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化学定制的阳离子抗生素辅助剂,向双价子,以克服格拉姆阴性细菌中的碳烯耐药性

Hao Tang1, Xiaomeng Zhao1, Mengsi Sun2

  • 1Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P. R. China.

Science advances
|October 22, 2025
PubMed
概括

一种新的离子辅助剂,TINA,有效地打击超级细菌中的金属β-乳糖酶 (MBL) 耐药性. 它通过向MBL和脂聚糖 (LPS) 来恢复抗生素的有效性,为抵抗耐药格兰氏阴性病原体提供了一个有希望的策略.

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