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流动驱动的磁性微导管用于超选择性动脉栓塞.

Lucio Pancaldi1, Ece Özelçi1, Mehdi Ali Gadiri1

  • 1Institute of Mechanical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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概括

研究人员开发了新的磁性微导管,用于导航微小,难以到达的大脑动脉. 这一突破使得医生以前无法获得的脑血管疾病的新型微创治疗方法成为可能.

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科学领域:

  • 生物医学工程 生物医学工程
  • 干预神经病学 干预神经病学
  • 医疗机器人 医疗机器人

背景情况:

  • 最少侵入性内血管技术已经改变了脑血管疾病的治疗.
  • 传统的导管注射受到仪器直径和刚度的限制,限制了对远距离大脑血管系统的访问.
  • 大脑复杂的血管网络的很大一部分仍然无法用于诊断和治疗.

研究的目的:

  • 克服传统导管的机械限制,以获得以前无法达到的大脑血管系统.
  • 开发和证明用于内血管导航的新型超微微化磁性微导管的有效性.
  • 为了使药物的超选择性输送到远端和曲动脉.

主要方法:

  • 充气式,平管磁性微导管的微工程,以提高灵活性和导航.
  • 开发一个紧的磁性方向盘平台,与双平面光学相兼容.
  • 在猪模型中进行体内测试,以评估导航,跟踪和输液能力.

主要成果:

  • 证明了安全而轻松的导航和跟踪动脉,其大小为180微米,曲率高.
  • 成功地进行了对比剂和栓塞液体剂的超选择性输液.
  • 磁性微导管利用血液流动进行内血管导航,克服机械障碍.

结论:

  • 开发的磁性微导管技术提供了前所未有的远距离和曲动脉的访问.
  • 这项创新对诊断和治疗脑血管疾病,包括动脉瘤,中风和瘤具有重大潜力.
  • 该技术可以适应在各种器官系统中进行向药物或基因输送,提高精度和安全性.