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Updated: Jan 14, 2026

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可编程癌症亚型评估器通过多重保证的催化DNA计算电路

Ruomeng Li1,2, Xue Gong2, Jinhua Shang2

  • 1Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, P. R. China.

Journal of the American Chemical Society
|October 22, 2025
PubMed
概括

这项研究引入了用于双微RNA检测的紧型DNA计算电路,使得乳腺癌亚型的精确分类成为可能. 这种可编程的癌症评估器为临床诊断提供了高准确度.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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