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Updated: Jan 14, 2026

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设计,合成和生物评估新型核心基架修改的HIV-1蛋白酶抑制剂,以克服抗药性

Huiyu Zhou1, Yu Gao1, Qingqing Yang2

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P. R. China.

Journal of medicinal chemistry
|October 22, 2025
PubMed
概括

新的HIV-1蛋白酶抑制剂被开发用于对抗抗药性. 化合物20a表现出强烈的活性和优越的耐药性,其前药物20a-D显示出改善的ADME特性.

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