与代谢功能障碍相关的脂肪性肝病,心脏代谢风险因素和心血管疾病
Lærke Kristine Kyhl1, Børge Grønne Nordestgaard1, Anne Tybjærg-Hansen2
1Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
Atherosclerosis
|October 22, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球健康,将脂肪性肝与心脏代谢风险联系起来. 这篇评论探讨了MASLD.
科学领域:
- 肝病学和胃肠道学
- 心脏病学 心脏病学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球超过三分之一的成年人,构成了重大的公共卫生挑战.
- MASLD是美国末期肝病和肝移植的主要原因,也是代谢和心血管疾病的主要风险因素.
- 诊断MASLD需要脂肪肝加上心脏代谢风险因素,但这些因素与脂肪肝之间的联系尚不清楚.
研究的目的:
- 为了阐明心脏代谢风险因素和MASLD中的脂肪肝之间的关联.
- 审查将心脏代谢风险因素与MASLD发展联系起来的病理生理机制.
- 检查MASLD与心血管疾病的联系,并讨论当前的治疗指南和制药策略.
主要方法:
- 审查有关MASLD病理生理学和临床关联的现有文献.
- 对连接心脏代谢风险因素与脂肪肝的病理生理机制的分析.
- 综合目前的指导方针和新兴的药物治疗MASLD,强调心血管风险管理.
主要成果:
- 提供了MASLD的全面概述,详细说明其与普遍风险因素的关联.
- 解释了MASLD导致心血管疾病的机制,可能是通过非常低密度脂蛋白.
- 概述了基于既定指南的MASLD患者目前的临床方法和管理策略.
结论:
- 本综述巩固了MASLD的临床方面,从风险因素识别到患者的治疗结果.
- 它强调了解MASLD与心血管疾病之间的联系对于有效管理的重要性.
- 提供了对MASLD患者推的临床处理和治疗方法的见解.
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