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Updated: Jan 14, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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鉴定了一种新型的PDE4抑制剂,其灵感来自于氨酸衍生型的氨酸

Christine Coffey1, Alexander F Perhal1, Wito Richter2

  • 1Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Josef-Holaubek-Platz 2, Vienna, 1090, Austria.

European journal of medicinal chemistry
|October 22, 2025
PubMed
概括

研究人员选了165种莱奥利金类型的固酶4 (PDE4) 抑制. 他们发现了一种新的PDE4抑制剂,LT-104A,在体外表现出强大的抗炎活性.

关键词:
在体外抗炎药物.在Leoligin中使用.巨细胞是一个巨细胞.自然产品是天然产品.基化酶 4 的作用结构与活动的关系.在CAMP中,我们可以使用cAMP.

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