在抑制情感反应期间,在精神分裂症中减弱的甲基频段活动和交叉频率合在精神分裂症中
Jacob D Kraft1, Takakuni Suzuki2, Margo W Menkes3
1Department of Psychology, University of South Dakota, Vermillion, SD, USA.
概括
精神分裂症与认知控制任务期间异常的甲基波段神经活动有关. 这项研究发现,与健康对照人群相比,精神分裂症患者的乙太功率和合率下降,影响了表现.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 认知控制缺陷是精神分裂症 (SZ) 的标志.
- 这些缺陷背后的神经机制,特别是频振荡及其与马频段活动的合,仍然不清楚.
- 这项研究调查了这些神经活动在SZ与双相情感障碍 (BD) 和健康对照 (HC) 相比.
研究的目的:
- 在情感认知控制任务中检查甲频段神经振荡活动和甲-玛交叉频率合.
- 将这些神经测量与精神分裂症 (SZ),双相情感障碍 (BD) 和健康对照 (HC) 个体之间的神经测量进行比较.
- 研究这些群体中神经活动和行为表现之间的关系.
主要方法:
- 32名SZ,67名BD和48名HC参与者在电脑电图 (EEG) 记录过程中完成了一项带有情绪刺激的情感Go/No-Go任务.
- 时间频率分解量化了theta频段功率和试验间相一致性 (ITPC) 在中线前端-中心区域.
- 甲-马相幅度合 (PAC) 被分析到本地 (中线前线) 和跨区域 (中线前线甲和顶马).
主要成果:
- 与HC相比,患有SZ的个体表现出明显下降的中线前额 teta 功率,ITPC 和局部 teta-gamma PAC.
- 对于这些指标,BD集团显示了SZ和HC集团之间的中间值.
- 泰达功率,ITPC和PAC与行为表现相关,特别是在SZ组.
结论:
- 精神分裂症与在情感认知控制过程中与theta相关的神经活动的广泛异常有关.
- 这些异常包括塔波段的振幅,相一致性和与玛波段活动的交叉频率协调.
- 这些发现突出了被破坏的达网络动态在精神分裂症中观察到的认知障碍中的作用.
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