口腔医学中的4D打印智能水凝:当前的应用和未来的前景
Yaping Yin1, Ziming Wei2, Bingxu Lu1
1Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomtology, Southern Medical University, Guangzhou, PR China.
Journal of the mechanical behavior of biomedical materials
|October 22, 2025
概括
4D打印的水凝对个性化口腔疗法充满希望,提供可编程的配件和药物输送. 这些智能材料的临床翻译需要进一步的研究和标准化验证.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 口腔医学是指口腔医学.
背景情况:
- 4D打印利用刺激反应的水凝,随着时间的推移改变形状或功能.
- 这些智能材料为先进的治疗应用提供了独特的功能.
研究的目的:
- 系统地审查4D打印的水凝平台,刺激响应方法和口腔医学中的应用.
- 确定转化解决方案,以推动实验室研究向临床实践推进.
主要方法:
- 在PubMed,Web of Science和Google Scholar的系统文献搜索中,使用诸如"4D打印"和"刺激响应水凝"等关键词.
- 数据提取的重点是印刷平台,材料,刺激类型,实验模型,结果和转化因素.
- 提取的发现的叙述综合.
主要成果:
- 4D打印的水凝表现出可编程的变形,适合合规格的配件和可调节的自愈力学.
- 它们使治疗剂的时空传递成为可能,并在临床前模型中显示细胞相互作用和骨融合的改善.
- 局限性包括不一致的报告,制造参数差距和临床翻译数据的稀缺性.
结论:
- 4D打印的水凝对个性化口腔疗法具有前景,但需要统一的设计-验证-监管途径.
- 主要优先事项包括在口内条件下进行多因素验证,平衡反应能力和强度,并推进临床试验.
- 协调进步至关重要,以加快从实验室到临床的转化.
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