癌症患者使用他类药物:药物相互作用和他类药物的使用
Emily Chou1, Carlo S Legasto2, Alan K Chin2
1Department of Medicine, University of California Irvine Medical Center, Orange, California, USA.
JACC. Advances
|October 22, 2025
概括
类他类药物和癌症疗法之间的药物相互作用很常见,大多数需要监测而不是禁忌. 根据癌症类型,他类药物的使用有所不同,因此需要对患者进行个性化风险评估.
科学领域:
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
- 心血管医学 心血管医学
背景情况:
- 心血管疾病 (CVD) 和癌症具有共同的风险因素.
- 用于预防心血管疾病的他类药物可能与癌症治疗相互作用.
- 类他类药物和瘤学药物之间的药物相互作用 (DDI) 是一个临床问题.
研究的目的:
- 量化和描述通常处方的他类药物和最近的瘤学药物之间的DDI.
- 评估不同癌症患者群体的他类药物处方趋势.
主要方法:
- 对使用UpToDate Lexidrug的5种他类药物的相互作用进行了FDA查的瘤药物批准 (2019年6月至2024年6月).
- 将相互作用的严重程度分为5个风险级别.
- 通过对20项PubMed索引的观察性研究进行范围审查,分析了他类药物处方率.
主要成果:
- 在138种瘤药物中,33%的药物与他类药物发生了DDI;simvastatin的相互作用率最高.
- 大多数相互作用 (88%) 是C级 (需要监测);X级 (禁忌) 相互作用发生在阿达格拉西布,图卡提尼布和阿斯基米尼布.
- 在前列腺癌 (53%) 和肺癌 (32%) 中,他类药物的使用率最高,在肝癌 (8%) 和乳腺癌 (10%) 中最低.
结论:
- 立方体瘤剂DDI频繁,但很少有禁忌,强调监测.
- 在不同类型的癌症中,他类药物的使用模式显著不同.
- 个性化风险效益评估对于指导癌症患者使用他类药物治疗至关重要,考虑到预后,心血管疾病风险和潜在的DDI.
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