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Updated: Jan 14, 2026

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在三阴性乳腺癌细胞中抑制NEDD4通过β-TrCP/YAP/ECM轴重新编程瘤免疫微环境

Nan Su1, Wenhua Lian1, Baoding Zhang1

  • 1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China; State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China; Cancer Research Center of Xiamen University, Xiamen 361102, China.

Cell reports. Medicine
|October 22, 2025
PubMed
概括

准NEDD4,一种E3泛素酶,可以将"冷"的三阴性乳腺癌 (TNBC) 瘤转化为"热"的瘤. 抑制NEDD4增强了CD8+T细胞的透,提供了一个有前途的新TNBC治疗策略.

关键词:
E3 无处不在的合酶抗瘤免疫力 免疫力三重阴性乳腺癌是什么瘤微环境是一个微环境.

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