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Updated: Jan 6, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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蛋白质语言模型监督 motif-scaffolding 设计使用 GPDL

Bo Zhang1, Kexin Liu1, Zhuoqi Zheng1

  • 1State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

International journal of biological macromolecules
|October 22, 2025
PubMed
概括

语言生成蛋白质设计模型 (GPDL) 为蛋白质设计提供了一种新的方法,在生成多样化和准确的蛋白质结构方面表现优于现有的方法. 这种语言模型策略显示出创造各种应用的新型功能蛋白的前景.

关键词:
动机脚手架的问题蛋白质骨干的设计设计.蛋白质语言模型的模型

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