婴儿成长的进化遗传影响:将多基因分数,IGF-I和婴儿成长联系起来
Alexander S Busch1,2, Casper P Hagen2,3, Anders Juul2,3,4
1Department of General Pediatrics, University of Münster, Münster, Germany.
The Journal of clinical endocrinology and metabolism
|October 22, 2025
概括
在出生后,对婴儿成长的遗传影响发生了变化. 成人特征的多基因分数和IGF-I在婴儿早期变得更加重要,显示出动态的遗传过渡.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 人类遗传学 人类遗传学
- 增长和发展 增长和发展
背景情况:
- 婴儿期是快速成长的关键时期,受遗传学,荷尔蒙和营养的影响.
- 影响生长过渡的遗传因素,从与出生大小相关的转变为与成人身体大小相关的转变.
- 这些对婴儿生长的遗传影响的精确时间和发育轨迹需要进一步研究.
研究的目的:
- 检查出生体重,成人BMI,成人身高和胰岛素样生长因子I (IGF-I) 的多基因分数 (PGS) 之间的关系.
- 评估这些PGS与人体测量 (体重,身高) 和健康婴儿生命第一年IGF-I度的关系.
主要方法:
- 一项纵向队列研究,即哥本哈根迷你青春期研究,从2016年到2018年进行.
- 数据包括在第一年内对210名健康新生儿进行重复的人类测量和荷尔蒙评估.
- 分析的重点是体重,身长/身高和血清IGF-I的特定年龄标准偏差 (SDS) 评分,检查与各种PGS的关联.
主要成果:
- 出生体重的多基因分数与出生体重SDS相关,但与1年的体重SDS无关.
- 成年人BMI和身高的多基因分数与大约1岁时的体重和身高SDS显著相关.
- 成人IGF-I的多基因评分显示,在6个月和12个月时与IGF-I SDS有显著的关联,但在1个月时没有.
结论:
- 对生长的遗传影响在婴儿期经历了显著的演变.
- 遗传变异对出生大小的影响在产后减少.
- 与成人特征和IGF-I调节相关的多基因分数在婴儿期早期变得越来越重要,这表明婴儿成长的遗传基础发生了动态转变.
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