对使用灰色区进行血液输血传染性感染查的范围审查在献血者中
Rahul Chaurasia1, Suhasini Sil1, Chanchi Khiamniungan1
1Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Vox sanguinis
|October 22, 2025
概括
在献血者查中的灰色区域 (GZ) 呈现出一种小但显著的输血传染性感染 (TTI) 风险. 需要进一步的研究来规范管理这些不确定的TTI查结果的协议.
科学领域:
- 输血安全 输血安全
- 传染病查 传染病查
- 临床实验室科学 临床实验室科学
背景情况:
- 定性查试验用于输血传染性感染 (TTIs) 在献血者.
- 接近切线值的选值表明一个不确定的或灰色区域 (GZ).
- 本审查评估了GZ的反应性及其对TTI查的影响.
研究的目的:
- 评价研究的灰色区域 (GZ) 反应性在输血传染性感染 (TTI) 查在献血者.
- 分析GZ结果的后果,包括补充测试和供体管理.
主要方法:
- 在PubMed,Scopus和谷歌学者中进行了系统的文献搜索.
- 包括的研究分析了特征,TTI查方法和GZ反应性.
- 提取了关于GZ范围,重复/确认测试,供体随访和延期的数据.
主要成果:
- 十六项研究评估了各种TTI的GZ,包括HIV,HBV,HCV,梅毒,查加斯病和HTLV.
- GZ值各不相同 (0.5-1.2 S/CO),并且重复/确认测试协议是异质的.
- 虽然大多数验证试验是负的,但很大一部分是阳性或不确定的,有各种各样的捐赠者随访和推迟协议.
结论:
- 灰色区域评估表明,从GZ样本中获得TTI的风险很小但很大.
- 需要进行进一步的后续研究,以精确量化重复反应性或不确定样本的TTI风险.
- 为了提高血液安全,需要管理GZ样本的标准化协议.
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