体重指数变化对糖尿病发展的影响
Masahiro Okano1, Teruki Miyake2, Shinya Furukawa3
1Faculty of Medicine, Ehime University, Ehime 790-8577, Japan.
Endocrine journal
|October 22, 2025
概括
体重指数 (BMI) 的显著变化会影响糖尿病 (DM) 的发病. 增加2个或更多,或每年增加0.3个或更多,会增加DM风险,特别是在年轻人中.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 高体重指数 (BMI) 是已知的糖尿病 (DM) 的风险因素.
- 关于BMI变化与DM发病之间的联系的证据有限.
- 年度BMI变化对DM发病率的具体影响尚不清楚.
研究的目的:
- 研究BMI变化与患DM的风险之间的关联.
- 为了确定每年BMI变化 (kg/m2/年) 对DM发病的影响.
- 分析BMI变化对DM发病率的年龄分层影响.
主要方法:
- 分析了13949名参与者 (21-81岁) 的数据,他们在2003年4月至2021年3月期间至少进行了两次年度健康检查.
- 评估BMI变化 (总和年) 作为新发DM的预测因素.
- 多变量回归分析根据多种临床和人口因素进行调整.
主要成果:
- 共有462名参与者出现了新发的DM.
- 体重指数变化<-2与较低的DM风险相关,而≥2 (尤其是≥4) 的变化与较高的DM风险相关.
- 每年BMI变化≥0.3/年与DM发病率增加显著相关,特别是在年轻和中年人群中.
结论:
- 体重指数的变化与患DM的风险有显著的相关性.
- 临床医生应考虑BMI趋势,特别是BMI增加≥2或每年增加≥0.3,用于DM预防策略.
- 这些发现对年轻和中年人群最为相关.
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