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染色素A阳性胃肠内分泌细胞的胎儿发育重新审视:使用人类胎儿的组织学研究

Ji Hyun Kim¹, Zhe-Wu Jin², Eri Miyamoto³

¹Department of Anatomy, Jeonbuk National University Medical School, Jeonju, Korea.

Anatomy & cell biology

|October 22, 2025

概括

最初的胃肠内分泌细胞 (GIECs) 在胎儿的肠道中出现,与结肠相比,十二指肠和阴肠的早期发育. 在正在发展的GIEC附近也观察到calretinin阳性细胞.

科学领域:

发育生物学是发展生物学.
胃肠病学胃肠病学
神经科学是一个神经科学.

背景情况:

胃肠内分泌细胞 (GIECs) 在肠道功能中起着至关重要的作用.
最初的GIEC发展的确切时间和地点尚未完全理解.
已知神经元与成熟肠道中的GIEC相互作用.

研究的目的:

研究GIEC在人类发育中的胎儿肠道中的初始外观和地形分布.
在早期发育过程中检查GIEC和神经元之间的关系.
为了确定GIEC在胎儿肠道不同部分的发育时间表.

主要方法:

胎儿肠道部分的免疫组织化学染色 (8-18周妊娠年龄).
对染色素阳性细胞 (GIEC标记物的标记物) 和对卡列素阳性细胞的分析.
在十二指肠,阴,直肠和结肠中GIEC分布的比较.

主要成果:

丰富的染色素阳性GIEC在十二指肠和十足肠中发现了8-18周.
最初的GIEC在直肠中出现的时间比结肠更早,早期标本中缺乏它们.
与小肠相比,结肠中观察到的GIEC密度明显较低.
在十二指肠和结肠中发现了calretinin阳性细胞,可能靠近GIECs.

结论:

孕产妇的GIEC首先出现在胎儿的近端和远端肠道中,在不同部分有不同的发育时间表.
结肠显示,与小肠相比,GIECs的殖民延迟和不那么密集.
卡尔雷丁宁阳性细胞可能与胎儿肠道中发展的GIEC有着密切的地形关系.

关键词:

门过渡区门过渡区染色蛋白素A是一种染色素.胃肠内分泌细胞胃肠内分泌细胞人类胎儿人类胎儿身体的生理.

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