多层网络的变化与具有认知障碍和基因表达特征的多层网络的变化相关,这些变化发生在患有特异性普遍性的儿童中
Haifeng Ran1, Qiane Yu1, Yue Hu1
1Department of Radiology, The Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, 563000, China.
Scientific reports
|October 22, 2025
概括
患有特异性普遍性 (IGE) 的儿童表现出改变的动态大脑网络,影响认知功能. 这些网络变化与特定的基因表达模式有关,为机制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 的研究研究.
背景情况:
- 异形性普遍性 (IGE) 影响大脑网络动态.
- 了解IGE相关神经变化的遗传基础至关重要.
研究的目的:
- 研究IGE儿童的动态大脑网络变化.
- 探索网络变化,认知功能和基因表达之间的相关性.
主要方法:
- 在26名IGE儿童和35名对照儿童的休息状态功能性MRI和认知评估中.
- 在时间变化的脑网络中分析模块变性 (MV).
- 使用艾伦人类大脑图谱和机器学习进行基因丰富分析.
主要成果:
- 患有IGE的儿童在传感动力/前对对面网络中显示了减少的MV,在默认模式网络 (DMN) 中显示了增加的MV.
- MV变化与口头,全尺度和性能智商分数相关.
- 转录组分析确定了985个基因,这些基因用于突触信号和神经活性联体受体相互作用,与网络变化相关.
结论:
- 在IGE中的动态大脑网络异常与认知缺陷有显著的关联.
- 基因表达模式与中观察到的网络功能障碍相关.
- 这些发现为IGE的神经和遗传机制提供了新的见解.
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