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黑素对晚期糖化终产品,炎症和氧化应激在腹腔透析患者的影响:一项随机对照试验

Mina Movahedian¹, Hadi Tabibi², Shahnaz Atabak³

¹Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Scientific reports

|October 22, 2025

概括

在腹腔透析 (PD) 患者中,补充黑素显著降低了心血管风险因素,如马隆迪甲 (MDA) 和高灵敏性C反应蛋白 (hs-CRP). 这项研究表明,黑可以减轻PD患者的炎症和氧化应激.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
心血管医学心血管医学
生物化学生物化学

背景情况:

心血管疾病 (CVD) 是患上腹腔透析 (PD) 的患者的主要并发症.
先进的糖化终产物 (AGEs),炎症和氧化应激是PD患者心血管疾病风险的关键因素.
对于PD患者的这些危险因素,黑激素的治疗潜力在很大程度上仍未被探索.

研究的目的:

研究黑素补充剂对腹腔透析患者中氧化应激,炎症和AGE标志物的影响.
评估黑激素对该患者群体中特定心血管风险因素的影响.

主要方法:

进行了一项随机临床试验,涉及44名PD患者.
参与者被分配每晚接受5毫克的黑或安慰剂,持续10周.
测量了pentosidine,carboxymethyl lysine (CML),高灵敏性C反应蛋白 (hs-CRP),可溶性细胞间粘附分子1型 (sICAM-1),马隆迪甲基 (MDA) 和葡萄糖的血清水平.

主要成果:

与安慰剂 (P=0.03) 相比,氨酸的使用导致血清氨酸 (MDA) 水平显著降低 (P=0.03).
观察到血清高灵敏性C反应蛋白 (hs-CRP) (P=0.04),可溶性细胞间粘附分子1型 (sICAM-1) (P=0.02) 和托西丁 (P=0.03) 在黑素组的显著下降.
血清CML或葡萄糖在组内或组之间没有显著变化.

结论:

在PD患者中,每晚服用5毫克的黑激素有效降低了关键心血管风险因素,包括MDA,hs-CRP,sICAM-1和pentosidine.
黑素作为减轻氧化应激和炎症的治疗剂具有前景,从而可能降低腹膜透析患者的心血管疾病风险.

关键词:

高级糖化最终产品的高级糖化.炎症炎症是一种炎症.黑色素是什么黑色素是什么黑色素是什么氧化应激是一种氧化应激.腹膜透析是指腹膜透析.

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