来自先天性淋巴细胞的IL-26通过塑造微生物群组成来调节生命早期的肠上皮质平衡
Yazan Salloum1, Gwendoline Gros1, Keinis Quintero-Castillo2
1Institut Curie, PSL Research University CNRS UMR 3215, INSERM U934, 26 Rue d'Ulm, 75248 Paris Cedex 05, Paris, France.
The EMBO journal
|October 22, 2025
概括
介素-26 (IL-26) 通过控制微生物群组成,调节生命早期的肠道平衡. 这项研究揭示了IL-26的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 主体免疫系统和肠道微生物群的相互作用对于上皮质平衡至关重要,特别是在早期发育过程中.
- 在人体体内,具有杀菌性质的炎症性细胞因子 - - 人类介质素-26 (IL-26) 的活体功能在很大程度上是未知的.
- 动物模型不适合研究IL-26由于它在这些物种中不存在.
研究的目的:
- 调查IL-26在维持生命早期肠上皮质平衡中的作用.
- 探索IL-26影响肠道微生物群组成和上皮细胞动态的机制.
- 在发育中的肠道中识别IL-26的细胞来源.
主要方法:
- 使用斑马鱼 (Danio rerio) 作为实体IL-26功能的模型生物.
- 生成并分析了il26淘汰赛斑马鱼幼虫 (il26-/-).
- 在il26-/-幼虫中研究了上皮细胞的增殖,循环,DNA损伤和细胞群丰度.
- 评估了微生物群的组成,并确定了IL-26的细胞来源.
主要成果:
- il26-/-幼虫表现出肠道上皮细胞扩散的增加,更快的周转率,DNA损伤的增加和细胞群丰度的改变.
- 在il26-/-幼虫上皮质调节失调独立于IL-26正规受体,并与肠道失调有关.
- 在斑马鱼中,IL-26的杀菌活性保持不变,这表明它在微生物群调节中的作用.
- 先天性淋巴细胞 (ILC) 被确定为在发育中的肠道中IL-26的主要来源.
结论:
- 在生命早期,IL-26对于维持肠道平衡至关重要.
- 通过其杀菌活性,IL-26调节上皮细胞动态和微生物群组成.
- 涉及IL-26,ILCs,微生物群和肠上皮细胞的调节电路对于肠道健康至关重要.
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