解码动态脂酶轨迹模式和急性胰腺炎的住院死亡率:在重症监护室的机器学习的见解
Yingyi Li1, Xiaoqiang Liu1, Xiaodong Zhu1
1Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, China.
European journal of medical research
|October 22, 2025
概括
急性胰腺炎 (AP) 患者的明显的脂酶模式显示出不同的死亡风险. 监测这些动态脂酶轨迹可以改善急性胰腺炎的风险分层和患者管理.
科学领域:
- 生物化学和临床诊断学
- 关键护理医学 关键护理医学
- 医疗信息学 医疗信息学
背景情况:
- 血清脂酶是急性胰腺炎 (AP) 的关键生物标志物.
- 了解动态脂酶模式及其在AP的预后意义是有限的.
- 这项研究研究了脂酶轨迹及其与AP患者住院死亡率的相关性.
研究的目的:
- 在急性胰腺炎 (AP) 患者中识别明显的脂酶轨迹表型.
- 评估这些脂酶表型在医院死亡率方面的预后价值.
- 探索AP风险分层和临床管理的潜在改进.
主要方法:
- 来自MIMIC-IV数据库的834名AP患者的回顾性分析.
- 隐性类轨迹建模 (LCTM) 来定义脂酶表型.
- 考克斯回归模型根据共变量调整,以评估死亡风险.
主要成果:
- 确定了三个脂酶轨迹表型:持续低 (第1类),极高/变量 (第2类) 和中度升高 (第3类).
- 2类患者年龄较大,并具有较高的并发症负担.
- 2类 (HR:2.21) 和3类 (HR:1.61) 与1类相比,在医院内死亡风险显著更高.
结论:
- 在AP患者中,明显的脂酶轨迹模式与住院死亡率的显著差异相关.
- 这些发现强调了监测AP中的脂酶动态的预后价值.
- 脂酶轨迹分析可以提高风险分层,并指导AP管理中的临床决策.
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