开发和验证一种风险预测模型,用于同时存在的中年和老年人中低腰痛抑郁症的风险预测模型
Kaixia Gao1,2,3,4, Meichi Yan1,5,3,4, Jinmeng Tao1,3,4
1Department of Rehabilitation Medicine, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
European journal of medical research
|October 23, 2025
概括
这项研究开发了一种实际的风险预测模型,用于识别患有腰部疼痛 (LBP) 的老年人抑郁症. 该模型有助于早期检测和有针对性的干预,以获得更好的患者结果.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 腰部疼痛 (LBP) 是中年和老年人普遍存在的疾病,造成重大负担.
- 伴随性抑郁症经常会使慢性LBP复杂化,使预后恶化.
- 在LBP患者中确定抑郁症预测因子对于早期检测和干预至关重要.
研究的目的:
- 开发和验证风险预测模型,以估计LBP患者的抑郁风险.
- 在这个人群中确定与抑郁症相关的关键预测因素.
- 支持对患有抑郁症的LBP患者的早期检测和及时干预策略.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据.
- 应用LASSO回归与交叉验证,从社会人口统计学,疼痛,行为,健康和心理因素中选择预测因素.
- 构建了一个后勤回归模型和一个名图,使用AUC,校准图和DCA评估性能.
主要成果:
- 包括1693名LBP参与者 (2018-2020年);抑郁症发病率为29.4%.
- 确定了关键预测因素:性别,教育,睡眠质量,慢性疾病,生活满意度,认知功能,疼痛严重程度和止痛药的使用.
- 命名图表显示了良好的区分 (AUC 0.736培训,0.718验证) 和临床实用性.
结论:
- 开发的名图表是评估LBP老年人抑郁风险的实用工具.
- 有助于早期识别有风险的个体.
- 支持有针对性的预防策略和临床实践,以改善患者管理.
相关概念视频
Depressive Disorders: MDD and Dysthymia
627
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
627
Depressive Disorders: Etiology
437
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
437


