全喉切除术后的嗅觉障碍:一项前性队列研究
Ly Xuan Quang1,2, Truong Thanh Tam2, Luong Huu Dang2
1Department of Otolaryngology, University Medical Center Ho Chi Minh City, Vietnam.
The Journal of international medical research
|October 23, 2025
概括
全喉切除术 (手术切除语音箱) 由于空气流量发生变化,导致显著的嗅觉障碍. 所有患者都经历了手术后减少嗅觉,突出了需要嗅觉康复的需要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 生活质量研究 研究 生命质量研究
背景情况:
- 整体喉切除术破坏了上下呼吸道,需要通过口腔口腔进行呼吸.
- 这种改变的空气流显著影响嗅觉功能,因为鼻腔空气流对于嗅觉至关重要.
研究的目的:
- 为了研究全喉切除术后嗅觉功能的减弱.
- 为了确定临床特征和术后嗅觉障碍之间的关联.
主要方法:
- 一项前性队列研究,涉及40名接受全喉切除术的患者.
- 嗅觉能力在手术前和手术后使用经过验证的嗅探棒测试进行评估.
- 分析了临床特征,以确定与嗅觉障碍的相关性.
主要成果:
- 在手术前,82.5%的患者有正常的气味 (正常气味),17.5%的患者有减少的气味 (低气味).
- 手术后,所有患者都出现了嗅觉障碍,87.5%的患者完全失去嗅觉 (厌氧症).
- 在喉腔切除术后观察到嗅觉功能的统计显著下降 (p < 0.001). 没有任何临床因素与衰弱显著相关.
结论:
- 嗅觉障碍是全喉切除术的常见和重大后果,对生活质量产生负面影响.
- 鼻腔空气流失和潜在的嗅觉上皮质变化是主要原因.
- 全球性的手术前咨询和术后嗅觉康复对所有患者至关重要.
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