功能性光膜成像探针泛度测量食道运动分类的验证2.0版本:对805名患者的研究
Ofer Z Fass1, Gaston Becherano2, John E Pandolfino1
1Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
功能性光膜成像探测器 (FLIP) 泛度测量v2.0有效地对食道运动进行分类,通常与高分辨率计量 (HRM) 诊断保持一致. 这种耐受良好的方法可以作为HRM的替代方案,用于诊断食道运动障碍.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 食道生理学 食道生理学
- 诊断内镜检查 诊断内镜检查
背景情况:
- 功能性光膜成像探头 (FLIP) 泛度测量用于评估镇静内镜期间的食道运动性.
- 在达拉斯共识中,FLIP全测运动分类最近更新到2.0版本 (v2.0).
- 高分辨率计量 (HRM) 诊断是基于芝加哥分类版本4.0 (CCv4.0).
研究的目的:
- 使用FLIP v2.0分类来描述食道运动.
- 为了将FLIP v2.0分类与FLIP v1.0和HRM/CCv4.0诊断进行比较.
- 评估FLIP泛度作为食道运动障碍的诊断工具.
主要方法:
- 分析了805名在两个高等医疗中心接受FLIP和HRM治疗的成年患者.
- 704名具有确定的CCv4.0诊断的患者组成了初级分析队列.
- 使用FLIP评估食管胃节 (EGJ) 开放和收缩反应 (CR),根据FLIPv1.0和v2.0标准进行分类.
主要成果:
- 在137名正常FLIP运动的患者中,93%的人在HRM上有正常或无效的食道运动 (IEM).
- 正常的FLIP运动性显示了99%的EGJ外流障碍的负预测值.
- 163名患有非性阻塞的FLIP患者 (降低EGJ开口,降低CR) 在HRM上有91%的确定的EGJ外流障碍率.
- 在HRM上,有43%的III型阿喀拉西亚患者被归类为在FLIP上患有性阻塞.
结论:
- FLIP 全度测量v2.0分类经常与HRM/CCv4.0诊断进行并行.
- FLIP泛度测量是一种耐受良好的程序.
- 在诊断食道运动障碍时,FLIP泛度测量补充或可以作为HRM的替代品.
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