压电驱动的Cu2+/Cu+转换策略用于放大杯和氧化应激
Xujian Yang1,2, Gao He3, Jiarui Wang1,2
1School of Rare Earths, University of Science and Technology of China, Hefei 230026, China.
ACS applied materials & interfaces
|October 23, 2025
概括
通过结合cuproptosis和反应性氧物种 (ROS) 生成,工程化的压电纳米片可以增强癌症治疗. 这种新的方法在临床前模型中显著抑制瘤生长.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
背景情况:
- 质亡是一种受调节的细胞死亡途径,在癌症治疗中面临效率挑战.
- 开发新的治疗策略对于改善癌症治疗结果至关重要.
研究的目的:
- 设计一个带有Cu的压电Bi4Ti3O12纳米板系统,用于协同性cuproptosis和ROS介导的瘤治疗.
- 为了研究将压电特性与铜价值调制相结合以提高癌症治疗的潜力.
主要方法:
- 压电Cu装载Bi4Ti3O12纳米片的制造.
- 超声波 (US) 刺激调节铜价值并产生压电场.
- 评估反应性氧物种 (ROS) 生产和cuproptosis诱导.
- 在小鼠乳腺癌模型中评估治疗疗效.
主要成果:
- 改造的纳米板表现出增强的压电系数 (d33 = 22.3 pm·V-1).
- 超声波刺激促进了电荷分离,加速了Cu2+/Cu+转换和ROS生成.
- 实现了一种协同的双瘤杀伤性途径,涉及放大和氧化应激.
- 在小鼠乳腺癌模型中观察到90.6%的瘤抑制率.
结论:
- 这项研究成功地将压电材料特性和铜价值转换结合起来,用于协同的癌症治疗.
- 这种方法为克服cuproptosis的局限性和增强乳腺癌治疗提供了一个有希望的策略.
- 这些发现为开发瘤学中先进的纳米材料提供了宝贵的见解.
相关概念视频
02:47Voltaic/Galvanic Cells
Spontaneous Chemical Reactions
Spontaneous redox reactions occur abundantly in nature. The chemical reaction occurring in a disposable AA battery powering our remote controls is one such example of a spontaneous redox reaction. Another example is the immersion of coiled copper wire into an aqueous silver nitrate solution. The reaction shows a gradual, visually impressive color change from colorless to bright blue and the formation of a grey precipitate on the copper wire. In this experiment,...
Spontaneous redox reactions occur abundantly in nature. The chemical reaction occurring in a disposable AA battery powering our remote controls is one such example of a spontaneous redox reaction. Another example is the immersion of coiled copper wire into an aqueous silver nitrate solution. The reaction shows a gradual, visually impressive color change from colorless to bright blue and the formation of a grey precipitate on the copper wire. In this experiment,...
01:17Controlled-Potential Coulometry: Electrolytic Methods
Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential ensures...
The chosen potential ensures...
01:08Electrodeposition
Electrodeposition is a technique used to separate an analyte from interferents by electrochemical processes. Here, the analyte is a metal ion that can be deposited on an electrode immersed in the sample solution. The electrochemical setup consists of an anode and a cathode. When an electric current is applied to the setup, oxidation occurs at the anode. At the cathode, which consists of a large metal surface, metal ions undergo reduction and deposit onto the surface.
Electrodeposition can...
Electrodeposition can...
01:24Electrochemical Systems
Electrochemical systems provide a fascinating insight into the dynamic interplay of charged species within various phases. One notable example is the interaction between a membrane permeable to K⁺ ions but not to Cl⁻ ions, separating an aqueous KCl solution from pure water. As K⁺ ions diffuse through the membrane, they generate net charges on each phase, leading to a potential difference between them.Similarly, when a piece of Zn is immersed in an aqueous ZnSO₄ solution, the Zn metal, composed...
01:28Electrochemical Cells
Electrochemical cells are systems that convert chemical energy into electrical energy or use electrical energy to drive chemical reactions. They consist of two electrodes in contact with an electrolyte, where redox reactions enable electron transfer. Most electrochemical cells include two half-cells connected by an external wire for electron flow and a salt bridge for ion flow. The salt bridge contains an electrolyte solution and maintains charge neutrality by allowing ions—not electrons—to...
01:24Types of Reversible Electrodes
For electrode reversibility to be maintained, all the reactants and products involved in the half-reaction must be present at the electrode. There are several types of reversible electrodes (half-cells).In metal-metal-ion electrodes, a metal balances electrochemically with a solution of its own ions. Examples are Cu2+|Cu and Zn2+|Zn. Metals that react with the solvent, like group 1 and most group 2 metals, which react with water, and zinc, which reacts with aqueous acidic solutions, cannot be...