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联合母体和父体低剂量N-Nitrosodimethylamine暴露:大鼠的母体变化和发育毒性

Julia Tavares Alves1, Luara Magalhães1, Julia Vitoria Francisco de Aquino1

  • 1Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista-UNESP, Botucatu, São Paulo, Brazil.

Birth defects research
|October 23, 2025
PubMed
概括

低剂量N-Nitrosodimethylamine (NDMA) 暴露在母老鼠中影响了母亲的健康和胎儿的发育,导致血细胞计数的变化和胎儿的超数肋骨增加. 这凸显了环境暴露水平的潜在风险.

关键词:
胚胎毒性 胚胎毒性环境污染物环境污染物胎儿的发育 胎儿的发育酸氨基酸的含量是多少骨架的异常情况.

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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