血压波动的低频振荡与来自神经成像的脑年龄之间的关联
Kevin S Heffernan1, Jill N Barnes2, Andrew S London3
1Department of Biobehavioral Sciences, Applied Physiology, Teachers College, Columbia University, New York, New York, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|October 23, 2025
概括
静脉血压波动的低频振荡与缓慢的大脑衰老有关. 这一发现表明,随着时间的推移,血压调节与大脑健康之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 衰老研究研究 衰老研究
背景情况:
- 血压变化 (BPV) 和它与大脑健康的关联是越来越感兴趣的领域.
- 血压的低频振荡 (LF-BPV) 可能反映了影响大脑的潜在生理过程.
- 脑年龄差距 (BrainAGE gap) 是大脑健康的指标,可以衡量相对于时间学年龄的加速或减缓大脑衰老.
研究的目的:
- 为了研究过去和并发的低频振荡之间的关系,在透静血压变化 (LF-BPV) 和BrainAGE差距.
- 为了确定血管运动标志物是否与大脑衰老有关.
- 探索心血管调节和神经成像衍生的大脑健康之间的潜在联系.
主要方法:
- 分析了来自美国中年期 (MIDUS) 研究的110名成年人.
- 从使用光谱分解的节拍对节拍血压波形中得出LF-BPV.
- 从MRI扫描中估计BrainAGE,BrainAGE差距计算为大脑年龄减去时间年龄.
主要成果:
- 过去更高的透性LF-BPV与减少的BrainAGE差距显著相关 (β = -2.24,p = 0.022).
- 较高的同时扩张的LF-BPV也与减少的BrainAGE差距有显著的关联 (β = -1.90,p = 0.037).
- 这些关联在调整相关共变量后仍然显著.
结论:
- 静脉血压波动的低频振荡与BrainAGE差距有关,表明大脑衰老速度较慢.
- 根据LF-BPV的指示,血管运动的减少可能导致大脑加快衰老.
- 这些发现凸显了心血管健康在维持整个寿命的脑部健康方面的重要性.
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