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在腹腔镜妇科手术后预防性flurbiprofen axetil用于睡眠-疼痛-炎症调节:一个前性的平行组随机对照试验

Xin Huang¹, Wenxin Wei^2,3, Zhihao Leng⁴

¹Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in pharmacology

|October 23, 2025

概括

在接受妇科手术的患者中,手术前的flurbiprofen axetil显著改善了术后疼痛和睡眠质量. 这种先发制人的方法还减少了炎症和恶心,优化了恢复.

科学领域:

麻醉学和疼痛管理
手术恢复优化手术恢复的优化
药理干预药理干预

背景情况:

手术后的疼痛,炎症和睡眠障碍在腹腔镜妇科手术后很常见,影响恢复.
一种NSAID,flurbiprofen axetil,用于治疗外科手术期间的疼痛,但其对睡眠质量的影响还未得到充分研究.
对于睡眠结果,NSAID管理的最佳时间 (手术前与术后) 是一个争论.

研究的目的:

为了研究手术前与术后flurbiprofen axetil对疼痛,炎症和睡眠质量的影响.
评估flurbiprofen axetil在腹腔镜妇科手术后增强康复中的作用.

主要方法:

一项前性随机对照试验,涉及98名接受腹腔镜妇科手术的患者.
患者在手术前15分钟 (PreFA组) 或在手术结束时 (PostFA组) 接受了flurbiprofen axetil.
主要结局包括疼痛 (VAS),睡眠质量 (AIS) 和炎症标志物 (SII,NLR,MLR),在手术前和手术后24小时和72小时进行评估.

主要成果:

在手术后24小时和72小时,PreFA组的疼痛评分 (VAS) 显著降低.
在手术后的第1天和第3天,在PreFA组中观察到明显较低的睡眠障碍得分 (AIS).
在手术前给药导致炎症标志物 (SII,NLR,MLR) 降低,手术后恶心和吐减少.

结论:

在手术前使用flurbiprofen axetil可以改善术后疼痛和睡眠质量.
这种先发制人的NSAID策略有效地减少了炎症反应,改善了患者的康复.
施用flurbiprofen axetil的时间对于优化腹腔镜妇科手术的结果至关重要.

关键词:

弗鲁尔比烯乙烯乙烯的使用方法腹腔镜妇科手术腹腔镜妇科手术非类固醇抗炎药 (NSAIDs) 是一种非类固醇抗炎药.术后疼痛术后疼痛术后疼痛预防性镇痛预防性镇痛睡眠质量睡眠质量系统性炎症系统性炎症

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