新型营养炎症指数在IVIG不响应川崎病的预测价值:一项回顾性研究
1Department of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
像CALLY指数和CAR这样的新型营养炎症标志物可以预测川崎病 (KD) 患者的静脉注射免疫球蛋白 (IVIG) 耐药性,有助于早期治疗决策.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 炎症研究 炎症研究
背景情况:
- 川崎病 (KD) 是一种严重的儿科疾病.
- 静脉注射免疫球蛋白 (IVIG) 耐药性发生在一小部分KD患者中.
- 需要对IVIG耐药性的预测标记来指导治疗.
研究的目的:
- 评估与白蛋白相关的新型营养炎症标志物对KDIVIG耐药性的预测价值.
- 评估C反应蛋白-白蛋白-淋巴细胞 (CALLY) 指数,C反应蛋白与白蛋白比率 (CAR),中性粒细胞与白蛋白比率 (NAR),中性粒细胞百分比与白蛋白比率 (NPAR) 和预后营养指数 (PNI).
主要方法:
- 716名儿科KD患者 (2012-2023) 的回顾性分析.
- 统计分析包括单变量,二进制物流回归和接收器运行曲线 (ROC) 分析.
- 对CALLY指数,CAR,NAR,NPAR和PNI进行评估,以预测IVIG耐药性.
主要成果:
- 10.9%的患者患有IVIG耐药的KD.
- CAR,NAR和NPAR与IVIG耐药性正相关.
- 卡利指数和PNI显示与IVIG抗性的负相关性.
- 在ROC曲线下的面积 (AUC) 值在0.580 (NAR) 到0.725 (CALLY指数) 之间.
结论:
- 营养炎症指数 (CALLY,CAR,NPAR,PNI) 在预测KD中的IVIG耐药性方面表现有前途.
- 这些标记可能有助于识别需要强化治疗的患者.
- 与NAR相比,CALLY指数,CAR,NPAR和PNI表现出优异的预测性能.
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