在患有维生素D缺乏症的慢性病患者中,主要的不良事件发生

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Yu-Min Lin¹, Chia-Li Kao², Kuo-Chuan Hung³

¹Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Centre, Chiali, Tainan, Taiwan.

Frontiers in nutrition

|October 23, 2025

概括

慢性病 (CKD) 患者的维生素D缺乏 (VDD) 显著增加了重大脏不良事件 (MAKE) 的风险. 这凸显了监测维生素D水平对于更好地管理脏健康的重要性.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

慢性病 (CKD) 影响全球数百万人,而维生素D缺乏 (VDD) 是一种常见的并发症.
在CKD患者中,VDD和不良结局之间的相互作用需要进一步阐明.

研究的目的:

研究诊断为慢性病 (CKD) 的患者维生素D缺乏症 (VDD) 与重大脏不良事件 (MAKE) 之间的关联.

主要方法:

使用TriNetX全球协作网络进行了一项回顾性队列研究.
倾向性得分匹配 (PSM) 用于平衡VDD和对照组之间的基线特征.
主要结局是一年内MAKE的发生率,次要结局包括全因死亡率和住院治疗.

主要成果:

在PSM之后,在每个组中分析了29654名患者.
在VDD群体中,MAKE的风险显著增加 (HR,2.24;95% CI,2.08-2.41;p < 0.001).
在VDD组中也观察到所有原因死亡率 (HR,1.92;95% CI,1.82-2.02;p < 0.001) 和所有原因住院 (HR,1.19;95% CI,1.14-1.25;p < 0.001) 的风险增加.

结论:

维生素D缺乏与慢性脏病患者中严重脏不良事件的风险增加有关.
这些发现强调了维生素D状态在CKD患者临床管理中的关键作用.
解决VDD可能对减轻脏不良结果和改善患者预后至关重要.

关键词:

慢性脏疾病慢性脏疾病住院治疗住院治疗主要的脏不良事件死亡率死亡率维生素D缺乏症维生素D缺乏症

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