多发性硬化症引起的认知功能障碍的药理疗法选择:一个网络元分析
Zhuyuan Fan1, Dan Liu1, Guangwei Zhang1
1Department of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, Mongolia, China.
Frontiers in neurology
|October 23, 2025
概括
药理疗法在多发性硬化症 (MS) 的认知功能障碍方面表现有前途. 氨基胺可以改善记忆力,而阿托莫克赛丁可以增强各种认知测试,而里瓦斯蒂格明显示的副作用较少.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 认知功能障碍 (CD) 是患有多发性硬化症 (MS) 的患者的一个重大挑战.
- 积极寻求MS诱导的CD的有效药理干预措施.
- 目前的治疗选择需要全面的比较分析.
研究的目的:
- 进行一个网络元分析,比较MS患者中CD的药理疗法.
- 评估各种药物对认知测试表现的疗效.
- 评估和比较这些治疗方法的不良影响概况.
主要方法:
- 从PubMed,Embase,Cochrane图书馆和科学网络系统地检索随机对照试验 (RCT).
- 包括26项研究,涉及23839名多发性硬化症患者.
- 使用偏差风险工具进行质量评估,使用R.R.进行数据分析.
主要成果:
- 在MS引起的CD中,L-安非他胺显示出潜在的记忆改善.
- 阿托莫克赛丁在改善符号数字模式测试 (SDMT) 和加利福尼亚口语学习测试 (CVLT) 成绩方面表现出有效性.
- 与其他治疗方法相比,里瓦斯蒂格明的消化不良发病率较低.
结论:
- 在MS诱导的CD中,L-安非他胺,黑激素和阿托莫克赛丁对特定的认知领域显示出潜在的益处.
- 阿托莫克赛丁似乎是改善记忆和执行功能的有希望的药物.
- 当最大限度地减少胃肠道副作用是一个优先事项时,里瓦斯蒂格明可能是首选的选择.
更多相关视频
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
10.2K
08:53Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
1.5K
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
552
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
552
01:22Alzheimer's Disease: Treatment
811
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
811
01:24Parkinson's Disease: Treatment
972
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
972
01:23Antidepressant Drugs: MAOIs and Other Agents
806
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
806
01:26Psychosis: Goals of Pharmacotherapy
466
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
466
01:28Drug Therapy
239
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
239