齐普罗与普罗波用于经脊柱手术的老年患者的内科神经生理监测:一项随机对照试验
Gaofeng Fan1,2, Zhenzhen Hu1, Suyue Zheng3
1Department of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Drug design, development and therapy
|October 23, 2025
概括
在接受脊髓手术的老年患者中,西普罗显示出优越的血液动力稳定性和较少的神经生理抑制,与普罗波相比. 这表明西普罗可能会提高手术内神经生理学监测的质量.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 神经生理学 神经生理学
背景情况:
- 在手术内神经生理监测 (IONM) 对于脊柱手术至关重要.
- 麻醉剂可能会影响IONM信号,特别是在老年患者中.
- 对比不同麻醉剂的效果对于优化患者的治疗结果至关重要.
研究的目的:
- 为了比较醇与醇对运动唤起潜力 (MEP) 和体感觉唤起潜力 (SEP) 的影响.
- 在脊柱手术期间评估血液动力学稳定性,在老年患者中使用西普罗福尔或普罗福尔麻醉.
- 确定这些剂对IONM质量的影响.
主要方法:
- 一项随机试验,涉及60名接受IONM选择性脊柱手术的老年患者.
- 患者被分配给接受西普罗 (C组) 或普罗波 (P组).
- 主要结果包括T6的MEP和SEP幅度;次要结果包括延迟,血液动力学参数 (HR,MAP,BIS) 和不良事件.
主要成果:
- 与醇组相比,醇组在T6时显示出明显更高的MEP和SEP幅度.
- 两组之间没有观察到欧洲议会议员或欧洲社会党员延迟时间的显著差异.
- 齐普罗组表现出更好的血液动力稳定性,具有更高的MAP,降低了低血压发病率,并且对血管活性药物的需求更少.
结论:
- 与propofol相比,西普罗在接受脊髓手术的老年患者中提供了卓越的血液动力稳定性.
- 齐普罗显示,在不延长延迟时间的情况下,对MEP和SEP振幅的抑制较小.
- 这些发现表明,在这个人群中,西普罗可能会在脊柱手术期间改善IONM的质量.
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