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动脉输液化疗和栓塞治疗复发性/转移性软组织肉瘤的可行性和耐受性:一项回顾性探索性研究

Jing Li¹, Rui Liu², Bao-Rang Zhu¹

¹Department of Oncology, the Fifth Medical Center of PLA General Hospital, Beijing, 100071, People's Republic of China.

Drug design, development and therapy

|October 23, 2025

概括

动脉输液化疗栓塞 (AICE) 是对复发性/转移性软组织肉瘤 (STS) 的可行且耐受性良好的治疗方法. 这种方法有效地控制了疾病的进展,并改善了STS患者的生存结果.

科学领域:

在瘤学瘤学.
干预性放射学干预性放射学
手术瘤学手术瘤学

背景情况:

复发性/转移性软组织肉瘤 (STS) 存在重大治疗挑战.
目前的治疗策略需要优化,以改善患者的治疗结果.

研究的目的:

评估动脉输液化疗栓塞 (AICE) 的可行性和耐受性,用于复发性/转移性STS.
确定预后因素,以量身定制个性化治疗策略.

主要方法:

对113名以AICE治疗的复发性/转移性STS患者的回顾性分析.
使用卡普兰-梅尔曲线评估无进展生存 (PFS) 和整体生存 (OS).
通过单变量和多变量考克斯回归分析进行预后因素评估;根据SIR标准分级的不良事件.

主要成果:

中位数的OS是19.0个月,中位数的PFS是11.0个月;两年的OS和PFS率分别为45.1%和25.7%.
目标应答率 (ORR) 为37.2%,疾病控制率 (DCR) 为76.1%.
瘤大小,远程转移,术后治疗方案,病理差异化和NLR是OS和PFS的显著预后因素. 常见的不良事件包括疼痛,骨髓抑制和发烧,耐受性良好.

结论:

AICE在复发性/转移性STS中展示了可行性和良好的耐受性,提供了有效的疾病控制和生存益处.
瘤大小,转移,先前的治疗,分化和短期疗效是关键的预后指标.
需要进一步的前性研究来验证发现,并探索AICE与免疫疗法或向疗法的组合.

关键词:

动脉输液化疗栓塞动脉输液有效性有效性有效性.预后预后预后在安全方面,安全是安全的.软组织肉瘤软组织肉瘤

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