探索对空气污染的遗传敏感性及其对疾病风险和精确健康的影响:一个范围审查
1Faculty of Medicine, Universitas Trisakti, West Jakarta, DKI Jakarta, Indonesia.
AIMS public health
|October 23, 2025
概括
遗传易感性影响个人对空气污染的反应,影响健康结果. 了解基因与环境的相互作用是个性化健康策略和解决环境健康差异的关键.
科学领域:
- 环境健康 环境健康
- 遗传学 是一个遗传学.
- 毒理学 毒理学 毒理学
背景情况:
- 空气污染是一个重要的全球健康问题,不成比例地影响弱势群体.
- 主要污染物包括细颗粒物 (PM2.5),颗粒物 (PM10),二氧化 (NO2) 和氧化 (NOx).
- 遗传因素可能在个体对空气污染有害健康影响的敏感性中起作用.
研究的目的:
- 系统地审查遗传易感性在与空气污染暴露相关的健康结果中的作用.
- 在与空气污染相关的条件下探索基因与环境的相互作用.
- 确定影响对特定空气污染物的反应的遗传标记和途径.
主要方法:
- 对过去十年的16项同行评审研究进行了范围审查.
- 对调节对PM2.5,PM10,NO2和NOx反应的遗传因素的分析.
- 识别氧化应激,炎症和DNA修复等途径.
主要成果:
- 参与氧化应激,炎症和DNA修复的遗传标记和途径影响个人对空气污染物的反应.
- 多omics和机器学习是有前途的未来研究方向.
- 目前的发现受到长度研究和人口多样性的缺乏限制.
结论:
- 遗传易感性是空气污染对健康影响的关键因素.
- 需要使用先进的方法和多样化的群体进行进一步的研究.
- 了解基因与环境的相互作用对于精确的健康和政策制定至关重要.
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